OL-066 Cellular factors and HIV-1 reverse transcription
نویسندگان
چکیده
منابع مشابه
Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription
There is ample evidence that synthesis of HIV-1 proviral DNA from the viral RNA genome during reverse transcription requires host factors. However, only a few cellular proteins have been described in detail that affect reverse transcription and interact with reverse transcriptase (RT). HIV-1 integrase is an RT binding protein and a number of IN-binding proteins including INI1, components of the...
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Bourara et al. (1) reported that transcripts of the human immunodeficiency virus–type 1 (HIV-1) were subject to RNA editing in chronically infected cells. They observed multiple guanine-to-adenine (G-to-A) and cytosine-to-uracil (C-to-U) changes in several regions of the HIV-1 RNA; commonly, a G-to-A change in the untranslated leader was present exclusively in spliced HIV-1 messenger RNA (mRNA)...
متن کاملStrand Transfer and Elongation of HIV-1 Reverse Transcription Is Facilitated by Cell Factors In Vitro
Recent work suggests a role for multiple host factors in facilitating HIV-1 reverse transcription. Previously, we identified a cellular activity which increases the efficiency of HIV-1 reverse transcription in vitro. Here, we describe aspects of the activity which shed light on its function. The cellular factor did not affect synthesis of strong-stop DNA but did improve downstream DNA synthesis...
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Reverse transcription of retroviral genomes into double stranded DNA is a key event for viral replication. The very first stage of HIV reverse transcription, the initiation step, involves viral and cellular partners that are selectively packaged into the viral particle, leading to an RNA/protein complex with very specific structural and functional features, some of which being, in the case of H...
متن کاملCellular co-factors of HIV-1 integration.
To achieve productive infection, the reverse transcribed cDNA of human immunodeficiency virus type 1 (HIV-1) is inserted in the host cell genome. The main protein responsible for this reaction is the viral integrase. However, studies indicate that the virus is assisted by cellular proteins, or co-factors, to achieve integration into the infected cell. The barrier-to-autointegration factor (BAF)...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2011
ISSN: 1201-9712
DOI: 10.1016/s1201-9712(11)60130-6